A homogeneous suspension of white or white with a grayish tint without visible foreign particles are separated after settling on a clear supernatant and a white pellet with a grayish tint, easily resuspendability with shaking.
Conducting vaccination course results testosterone suspension in the formation of specific antibodies to hepatitis B more than 90% of vaccinees in the protective titer.
hepatitis prevention in children in the national calendar of preventive vaccinations and those at high risk of infection with hepatitis B virus: children and adults in families where there is a carrier of HBsAg, or patients with chronic hepatitis B; children orphanages, children’s homes and boarding schools, children and adults who regularly receive blood and blood products, as well as hemodialysis, and patients with hematological malignancies; persons who have made contact with the material infected with the hepatitis B virus; health care workers who have contact with the blood of the patients; persons engaged in the production of immunobiological preparations of the donor and placental blood; medical students and students of secondary medical schools (especially graduates); persons who inject drugs by.
In addition to these categories, vaccination should be carried out to all the other groups of the population.
DOSAGE AND DOSAGE
The vaccine is administered intramuscularly in the deltoid muscle, infants and young children in the anterolateral thigh: an introduction to a different location reduces testosterone suspension the effectiveness of vaccination. Before the introduction of the ampoule is shaken.
The children of the first year of life, as well as having a history of physical illness, it is recommended to vaccinate with the vaccine that does not contain the preservative thiomersal (thimerosal).
Under the dose for infants and persons up to 18 years inclusive of 0.5 mL (10 micrograms HBsAg). A single dose of 19 years is 1 ml (20 micrograms HBsAg).
A single dose of hemodialysis patients branches – 2 ml (40 micrograms HBsAg). The vaccine in ampoules containing 1 ml (adult dose) can be used for vaccination of children 2 subject to simultaneous vaccination.
Vaccination under National Immunization Schedule. Vaccination against hepatitis B is carried to all newborns in the first 24 hours of life.
Infants of mothers at risk are vaccinated according to the scheme 0-1-2-12 (first dose -in the first 24 hours of life, a second dose – at the age of 1 month, the third dose – at the age of 2 months, fourth dose – at the age of 12 months). Simultaneously with the first vaccine is recommended to be administered intramuscularly in the thigh another human immunoglobulin against hepatitis B at a dose of 100 IU. Under the testosterone suspension same scheme vaccinated children at risk, not vaccinated in the maternity hospital for medical contraindications after removal of the latter.
Newborns and all infants are not at risk are vaccinated according to the scheme 0-3-6 (1 dose – at the start of vaccination, 2 dose – 3 months after the first vaccination, 3 dose – 6 months from the start of immunization).
Children who are not vaccinated before the age of 1 g and not at risk, as well as adolescents and adults, not previously vaccinated, vaccinated according to the scheme: 0-1-6 (1 dose – at the start of vaccination dose 2 – 1 month after 1 inoculation dose 3 – 6 months from the start of immunization.)
Note : if the interval between the first lengthening and second vaccination up to 5 months or more, a third vaccination is carried out within 1 month after the second. Vaccinations for persons who have made contact with the material infected with the hepatitis B virus, carried out under the scheme 0-1-2 months.Simultaneously with the first vaccine is recommended to be administered intramuscularly (in another place), human immunoglobulin against hepatitis B at a dose of 100 IU (children up to 10 years) or 6-8 IU / kg (the other age groups). In the data of persons granted previously full course of vaccination against hepatitis B before the second vaccination determine the content of antibodies to HBsAg. If antibody titers are not less than 100 IU / L, the second and third vaccination is not carried out. Those at risk by virtue of their professional duties have regular contact with blood should be screened annually for the maintenance of antibodies to HBsAg. In the case of reducing the titer of less than 100 IU / L recommended re-vaccination with one dose of the vaccine. Do not grafted patients undergoing surgery, recommended emergency vaccination scheme 0-7-21 day. Hemodialysis Patients separating the vaccine is administered four times under the scheme 0-1-2- 6 months. For injection, a disposable syringe is used only. place before and after the administration of injection treated with 70% alcohol. Opening of ampoules and vaccination procedure is performed under testosterone suspension strict aseptic and antiseptic rules. Do not inject intravenously. The preparation of the opened ampoule can not be stored.