Hypercalcemia during pregnancy can cause defects in physical and mental development of the fetus. Since vitamin D3 and its metabolites into breast milk during pregnancy daily testosterone suspension half life dose of vitamin BZ should not exceed 600 and ME 1500 mg calcium. For older people, the need for calcium is 1.5 g / day of vitamin D3 – 0.5-1 thousand IU / day..
Dosing and Administration
Inside. The tablet is chewed. Doses for adults and children over 12 years – 1 tablet 2 times a day, morning and evening, preferably with meals, or individually, depending on the clinical picture.
Hyperphosphatemia, hypercalcemia, hypercalciuria, anorexia, polyuria, constipation, headache, stomach pain, diarrhea, myalgia, arthralgia, hypertension, arrhythmia, renal insufficiency, and allergic reactions.
Symptoms of hypervitaminosis of vitamin D.
The early (due to hypercalcemia): constipation testosterone suspension half life or diarrhea, dryness of the oral mucosa, headache, pollakiuria, nocturia, polyuria, anorexia, metallic taste, nausea, vomiting, unusual tiredness, weakness, hypercalcemia, hypercalciuria.
Late: bone pain, clouding of urine (appearance of hyaline casts in urine, proteinuria, leukocyturia), increased blood pressure, itching, photosensitivity of the eye, conjunctival hyperemia, arrhythmia, drowsiness, myalgia, nausea, vomiting, pancreatitis, gastralgia, weight loss, rarely – psychosis (a change of mentality and mood).
Symptoms of chronic intoxication with vitamin D (when administered within a few weeks or months to adults in doses of 20-60 kDa IU / day, children – 4.2 kDa IU / day): calcification of soft tissues, kidney, lungs, blood vessels, hypertension, renal and chronic heart failure (these effects most often occur when connecting to hypercalcemia hyperphosphatemia), violation of the growth in children (long-term use at a dose of 1.8 thousand. IU / day).
Treatment: removal of the drug, a diet low in calcium, consumption of large quantities of liquid, the appointment of glucocorticosteroids, and tocopherol, ascorbic acid, retinol, thiamine, in severe cases – intravenous administration of large amounts of 0.9% sodium chloride solution, furosemide, electrolytes, hemodialysis .
There is no specific antidote.
To exclude overdose in some cases recommended determination of blood calcium concentration ( “Cautions” see.).
Interaction with other drugs
The risk of hypercalcaemia increase testosterone suspension half life thiazide diuretics. Effect reduce phenytoin (increased rate of biotransformation), cholestyramine, steroids, calcitonin, and derivatives etidronovoy pamidronic acid, plicamycin, gallium nitrate, reduces the toxicity of vitamin A increases the rate of biotransformation barbiturates. It increases the toxicity of cardiac glycosides. Long-term therapy on the background of the simultaneous application of an antacid comprising magnesium and aluminum, increases their concentration in blood and the risk of toxicity (especially in the presence of chronic renal failure).
Cholestyramine, colestipol, mineral oil reduces the absorption of fat-soluble vitamins in the digestive tract and need to increase their dosage. It increases the absorption of phosphorus-containing drugs and the risk of hyperphosphataemia.
Together with the application of sodium fluoride interval between doses should be not less than 2 hours, with oral forms of tetracycline – at least 3 hours. The simultaneous use of other analogues of vitamin D3 increases the risk of hypervitaminosis.
When using doses up to 1000 IU / day, and when taking the drug continuously for several months, it is recommended periodic determination of serum calcium and phosphorus concentrations to avoid hypervitaminosis D3 and chronic hyperphosphatemia.
In order to prevent the development of hyperphosphatemia in patients with bone lesions of renal origin, the drug can be administered together with phosphate resources.
During treatment it is necessary to constantly testosterone suspension half life monitor the urinary excretion of calcium. In the case of urinary calcium, greater than 7.5 mg / day (300 mg / day), it is necessary to reduce the dose or to stop taking. clomiver